A multi - center study evaluating the current strategies for isolating 1 Staphylococcus aureus strains with reduced susceptibility to glycopeptides 2 3 Evaluation of GISA /
نویسندگان
چکیده
2 Bristol Centre for Antimicrobial Research and Evaluation (BCARE), Medical 10 Microbiology, Southmead Hospital, North Bristol Healthcare Trust, Bristol, BS10 11 5NB, United Kingdom. 3 Department of Medical Microbiology, School of Medicine, 12 Cardiff University, Heath Park, Cardiff, CF14 4XN, United Kingdom. 13 14 15 16 17
منابع مشابه
Staphylococcus aureus with reduced susceptibility to vancomycin in healthcare settings
Glycopeptide resistance in Staphylococcus aureus is a source of great concern because, especially in hospitals, this class of antibiotics, particularly vancomycin, is one of the main resources for combating infections caused by methicillin-resistant Staphylococcus aureus strains (MRSA). Reduced susceptibility to vancomycin (VISA) was first described in 1996 in Japan; since then, a phenotype wit...
متن کاملReduced expression of the atl autolysin gene and susceptibility to autolysis in clinical heterogeneous glycopeptide-intermediate Staphylococcus aureus (hGISA) and GISA strains.
OBJECTIVES To assess a link between resistance to Triton X-100 induced autolysis (TIA) and lowered atl expression in a collection of clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heterogeneous GISA (hGISA). METHODS Nine clinical GISA, 11 hGISA and 11 glycopeptide-susceptible S. aureus (GSSA), including three pairs of related isolates, were analysed using TIA assays. Lyso...
متن کاملEvaluation of the effectiveness of common hospital hand disinfectants against methicillin-resistant Staphylococcus aureus, glycopeptide-intermediate S. aureus, and heterogeneous glycopeptide-intermediate S. aureus.
BACKGROUND The presence of methicillin-resistant Staphylococcus aureus (MRSA) and glycopeptide-intermediate S. aureus (GISA) in hospitals poses a significant challenge to hospital infection control teams. The use of disinfectants for both surface and hand cleaning is an essential part of the infection control measures. OBJECTIVE To evaluate the effectiveness of common hospital hand disinfecta...
متن کاملCharacterization of passage-selected vancomycin-resistant Staphylococcus aureus strains of diverse parental backgrounds.
A series of 12 Staphylococcus aureus strains of various genetic backgrounds, methicillin resistance levels, and autolytic activities were subjected to selection for the glycopeptide-intermediate S. aureus (GISA) susceptibility phenotype on increasing concentrations of vancomycin. Six strains acquired the phenotype rapidly, two did so slowly, and four failed to do so. The vancomycin MICs for the...
متن کاملAutolytic properties of glycopeptide-intermediate Staphylococcus aureus Mu50.
Whole-cell autolytic activity of prototypical glycopeptide-intermediate Staphylococcus aureus (GISA) Mu50 was reduced versus that of hetero-GISA Mu3 and glycopeptide-susceptible S. aureus, consistent with other GISA strains. In contrast, autolytic activity was relatively high in Mu50 crude cell walls and autolysin extracts against purified cell walls, reflecting the complexities of autolytic ac...
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تاریخ انتشار 2006